Diferencia entre revisiones de «Remifentanilo»

Se elimina mediante hidrólisis del enlace éster por esterasas inespecíficas, tisulares y plasmáticas. Dada la gran presencia de esta esterasas, el sistema no es saturable y la [[semivida|vida media sensible al contexto]] permanece en torno a 5 minutos después de infusiones muy prolongadas (hasta 10 horas). Los metabolitos son virtualmente inactivos. Este perfil permite el uso de dosis altas o muy altas cuyos efectos desaparecen rápidamente, consiguiéndose así mayor estabilidad hemodinámica.<ref>Hoke JF, Cunningham F, James MK, Muir KT, Hoffman WE. Comparative pharmacokinetics and pharmacodynamics of remifentanil, its principle metabolite (GR90291) and alfentanil in dogs. J Pharmacol Exp Ther. 1997 Apr;281(1):226-32</ref>

 

 

The most common side effects reported by patients receiving this medication are a sense of extreme "dizziness" (often short lived, a common side effect of other fast-acting synthetic phenylpiperidine narcotics such as [[fentanyl]] and [[alfentanil]]) and intense itching ([[pruritus]]), often around the face. These side effects are often controlled by either altering the administered dose (decreasing or in some cases, increasing the dose) or by administering other [[sedative]]s that allow the patient to tolerate or lose awareness of the side effect.