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| Vías_administración = Intravenoso.
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Es un [[opioide]] agonista puro de los receptores muμ de la [[morfina]] potente, de acción ultracorta y no acumulable, que se emplea durante las intervenciones quirúrgicas y procedimientos dolorosos para suministrar analgesia y sedación.
== Farmacocinética ==
==Efectos secundarios==
Comunes a todos los [[opioides]]: nauseas, vómitos, prurito, mareo, hipotensión, bradicardia, rigidez muscular y depresión respiratoria.
Comunes a todos los opioides Remifentanil is a specific [[Opioid receptor|-receptor]] agonist. Hence, it causes a reduction in [[sympathetic nervous system]] tone, [[respiratory depression]] and [[analgesia]]. The drug's effects include a dose-dependent decrease in [[heart rate]] and [[arterial pressure]] and [[respiratory rate]] and [[tidal volume]]. [[Muscle rigidity]] is sometimes noted.
The most common side effects reported by patients receiving this medication are a sense of extreme "dizziness" (often short lived, a common side effect of other fast-acting synthetic phenylpiperidine narcotics such as [[fentanyl]] and [[alfentanil]]) and intense itching ([[pruritus]]), often around the face. These side effects are often controlled by either altering the administered dose (decreasing or in some cases, increasing the dose) or by administering other [[sedative]]s that allow the patient to tolerate or lose awareness of the side effect.
Because pruritus is due to excessive serum histamine levels, antihistamines such as diphenhydramine (benadryl) are often co-administered. This is done with care, however, as excessive sedation may occur.
Nausea can occur as a side effect of remifentanil, however, it is usually transient in nature due to the drug's short half life which rapidly removes it from the patient's [[Circulatory system|circulation]] once the infusion is terminated.
== Potency ==
Remifentanil has a similar potency to fentanyl
==Circumventing Naltrexone==
Remifentanil has been used with some success to circumvent [[naltrexone]] in patients who are in need of pain management.
==Regulation==
In [[Hong Kong]], Remifentanil is regulated under Schedule 1 of [[Hong Kong|Hong Kong's]] Chapter 134 ''Dangerous Drugs Ordinance''. It can only be used legally by health professionals and for university research purporses. The substance can be given by pharmacists under a prescription. Anyone who supply the substance without prescription can be fined $10000 (HKD). The penalty for trafficking or manufacturing the substance is a $5,000,000 ([[Hong Kong dollar|HKD]]) fine and life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a $1,000,000 (HKD) fine and/or 7 years of jail time.
==References==
{{Analgesics}}
[[CategoryCategoría:OpioidsOpioides]]
[[Categoría:Piperidinas]]
[[Category:Piperidines]]
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