Coenzima F420

La coenzima F420 u 8-hidroxi-5-deazaflavina es una coenzima involucrada en reacciones redox en los organismos metanógenos,^[1] en muchas Actinobacterias, y esporádicamente en otros linajes bacterianos. Es un derivado de la flavina.

Esta coenzima funciona como sustrato para las enzimas coenzima F420 deshidrogenasas,^[2] 5,10-metilentetrahidrometanopterina reductasa y metilentetrahidrometanopterina deshidrogenasa.^[3]^[4]

Una fuente natural particularmente rica en coenzima F420 es Mycobacterium smegmatis, en la cual varias docenas de enzimas utilizan F420 en lugar de su cofactor relacionado FMN que utilizan enzimas homólogas de otras especies.^[5]

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Referencias editar

↑ Deppenmeier U (2002). «Redox-driven proton translocation in methanogenic Archaea». Cell. Mol. Life Sci. 59 (9): 1513-33. PMID 12440773. doi:10.1007/s00018-002-8526-3.
↑ Fox JA, Livingston DJ, Orme-Johnson WH, Walsh CT (1987). «8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization». Biochemistry. 26 (14): 4219-27. PMID 3663585. doi:10.1021/bi00388a007.
↑ Hagemeier CH, Shima S, Thauer RK, Bourenkov G, Bartunik HD, Ermler U (2003). «Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase (Mtd) from Methanopyrus kandleri: a methanogenic enzyme with an unusual quarternary [sic] structure». J. Mol. Biol. 332 (5): 1047-57. PMID 14499608. doi:10.1016/S0022-2836(03)00949-5.
↑ GD; Geerts, WJ; Keltjens, JT; Van Der Drift, C; Vogels, GD (1991). «Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri». Biochim. Biophys. Acta. 1079 (3): 293-302. PMID 1911853. doi:10.1016/0167-4838(91)90072-8.
↑ Selengut JD, Haft DH (2010). «Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria.». J Bacteriol. 192 (21): 5788-98. PMC 2953692. PMID 20675471. doi:10.1128/JB.00425-10.

Enlaces externos editar

KEGG entry for F420

Datos: Q412727

[Deppenmeier02-1] Deppenmeier U (2002). «Redox-driven proton translocation in methanogenic Archaea». Cell. Mol. Life Sci. 59 (9): 1513-33. PMID 12440773. doi:10.1007/s00018-002-8526-3.

[Fox87-2] Fox JA, Livingston DJ, Orme-Johnson WH, Walsh CT (1987). «8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization». Biochemistry. 26 (14): 4219-27. PMID 3663585. doi:10.1021/bi00388a007.

[Hagemeier03-3] Hagemeier CH, Shima S, Thauer RK, Bourenkov G, Bartunik HD, Ermler U (2003). «Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase (Mtd) from Methanopyrus kandleri: a methanogenic enzyme with an unusual quarternary [sic] structure». J. Mol. Biol. 332 (5): 1047-57. PMID 14499608. doi:10.1016/S0022-2836(03)00949-5.

[GD-4] GD; Geerts, WJ; Keltjens, JT; Van Der Drift, C; Vogels, GD (1991). «Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri». Biochim. Biophys. Acta. 1079 (3): 293-302. PMID 1911853. doi:10.1016/0167-4838(91)90072-8.

[Selengut10-5] Selengut JD, Haft DH (2010). «Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria.». J Bacteriol. 192 (21): 5788-98. PMC 2953692. PMID 20675471. doi:10.1128/JB.00425-10.

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