CTBP1

Proteína 1 de unión al extremo C-terminal
	; Estructura tridimensional de la proteína CTBP1.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1hku
Identificadores
Símbolos	CTBP1 (HGNC: 2494) BARS; MGC104684
Identificadores; externos	OMIM: 602618 ; EBI: CTBP1; GeneCards: Gen CTBP1; UniProt: CTBP1;
Locus	Cr. 4 p16.3
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
1487
Q13363	n/a
NP_001012632	n/a
	v; t; e;
	[editar datos en Wikidata]

La proteína 1 de unión al extremo C-terminal (CTBP1) es una proteína codificada en humanos por el gen CTBP1.^[1]

CTBP1 es una proteína que posee la capacidad de unirse al extremo C-terminal de las proteínas de los adenovirus. Esta fosfoproteína es un represor transcripcional que puede jugar un importante papel durante la proliferación celular. Esta proteína, junto con el producto génico de un segundo gen estrechamente relacionado, CTBP2, pueden conformar un dímero. Ambas proteínas pueden también interaccionar con el grupo polycomb de un complejo proteico que participa en la regulación de la expresión génica durante el desarrollo. Se han descrito variantes transcripcionales de este gen por medio de splicing alternativo.^[2]

Interacciones

La proteína CTBP1 ha demostrado ser capaz de interaccionar con:

Referencias

↑ Katsanis N, Fisher EM (Apr de 1998). «A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3». Genomics 47 (2): 294-9. PMID 9479502. doi:10.1006/geno.1997.5115.
↑ «Entrez Gene: CTBP1 C-terminal binding protein 1».
↑ Oma Y, Nishimori K, Harata M (febrero de 2003). «The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP». Biochem. Biophys. Res. Commun. 301 (2): 521-8. PMID 12565893.
↑ Paliwal S, Pande S, Kovi RC, Sharpless NE, Bardeesy N, Grossman SR (marzo de 2006). «Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis». Mol. Cell. Biol. 26 (6): 2360-72. PMC 1430274. PMID 16508011. doi:10.1128/MCB.26.6.2360-2372.2006.
↑ Chakraborty S, Senyuk V, Sitailo S, Chi Y, Nucifora G (noviembre de 2001). «Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles». J. Biol. Chem. 276 (48): 44936-43. PMID 11568182. doi:10.1074/jbc.M106733200.
↑ Izutsu K, Kurokawa M, Imai Y, Maki K, Mitani K, Hirai H (mayo de 2001). «The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling». Blood 97 (9): 2815-22. PMID 11313276.
↑ Li S, Weidenfeld J, Morrisey EE (enero de 2004). «Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions». Mol. Cell. Biol. 24 (2): 809-22. PMC 343786. PMID 14701752.
↑ Zhang CL, McKinsey TA, Lu JR, Olson EN (enero de 2001). «Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor». J. Biol. Chem. 276 (1): 35-9. PMID 11022042. doi:10.1074/jbc.M007364200.
↑ ^a ^b Melhuish TA, Wotton D (diciembre de 2000). «The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF». J. Biol. Chem. 275 (50): 39762-6. PMID 10995736. doi:10.1074/jbc.C000416200.
↑ Sundqvist A, Sollerbrant K, Svensson C (junio de 1998). «The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex». FEBS Lett. 429 (2): 183-8. PMID 9650586.
↑ Koipally J, Georgopoulos K (junio de 2000). «Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity». J. Biol. Chem. 275 (26): 19594-602. PMID 10766745. doi:10.1074/jbc.M000254200.
↑ Perdomo J, Crossley M (diciembre de 2002). «The Ikaros family protein Eos associates with C-terminal-binding protein corepressors». Eur. J. Biochem. 269 (23): 5885-92. PMID 12444977.
↑ Mirnezami AH, Campbell SJ, Darley M, Primrose JN, Johnson PW, Blaydes JP (julio de 2003). «Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription». Curr. Biol. 13 (14): 1234-9. PMID 12867035.
↑ Xia ZB, Anderson M, Diaz MO, Zeleznik-Le NJ (julio de 2003). «MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein». Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8342-7. PMC 166231. PMID 12829790. doi:10.1073/pnas.1436338100.
↑ Castet A, Boulahtouf A, Versini G, Bonnet S, Augereau P, Vignon F, Khochbin S, Jalaguier S, Cavaillès V (2004). «Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition». Nucleic Acids Res. 32 (6): 1957-66. PMC 390375. PMID 15060175. doi:10.1093/nar/gkh524.
↑ Perissi V, Scafoglio C, Zhang J, Ohgi KA, Rose DW, Glass CK, Rosenfeld MG (marzo de 2008). «TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints». Mol. Cell 29 (6): 755-66. PMC 2364611. PMID 18374649. doi:10.1016/j.molcel.2008.01.020.
↑ Alpatov R, Munguba GC, Caton P, Joo JH, Shi Y, Shi Y, Hunt ME, Sugrue SP (diciembre de 2004). «Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene». Mol. Cell. Biol. 24 (23): 10223-35. PMC 529029. PMID 15542832. doi:10.1128/MCB.24.23.10223-10235.2004.
↑ Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH (abril de 1999). «Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage». J. Biol. Chem. 274 (16): 11334-8. PMID 10196224.
↑ Schaeper U, Subramanian T, Lim L, Boyd JM, Chinnadurai G (abril de 1998). «Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif». J. Biol. Chem. 273 (15): 8549-52. PMID 9535825.

Datos: Q5014533

[pmid9479502-1] Katsanis N, Fisher EM (Apr de 1998). «A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3». Genomics 47 (2): 294-9. PMID 9479502. doi:10.1006/geno.1997.5115.

[2] «Entrez Gene: CTBP1 C-terminal binding protein 1».

[pmid12565893-3] Oma Y, Nishimori K, Harata M (febrero de 2003). «The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP». Biochem. Biophys. Res. Commun. 301 (2): 521-8. PMID 12565893.

[pmid16508011-4] Paliwal S, Pande S, Kovi RC, Sharpless NE, Bardeesy N, Grossman SR (marzo de 2006). «Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis». Mol. Cell. Biol. 26 (6): 2360-72. PMC 1430274. PMID 16508011. doi:10.1128/MCB.26.6.2360-2372.2006.

[pmid11568182-5] Chakraborty S, Senyuk V, Sitailo S, Chi Y, Nucifora G (noviembre de 2001). «Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles». J. Biol. Chem. 276 (48): 44936-43. PMID 11568182. doi:10.1074/jbc.M106733200.

[pmid11313276-6] Izutsu K, Kurokawa M, Imai Y, Maki K, Mitani K, Hirai H (mayo de 2001). «The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling». Blood 97 (9): 2815-22. PMID 11313276.

[pmid14701752-7] Li S, Weidenfeld J, Morrisey EE (enero de 2004). «Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions». Mol. Cell. Biol. 24 (2): 809-22. PMC 343786. PMID 14701752.

[pmid11022042-8] Zhang CL, McKinsey TA, Lu JR, Olson EN (enero de 2001). «Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor». J. Biol. Chem. 276 (1): 35-9. PMID 11022042. doi:10.1074/jbc.M007364200.

[pmid10995736-9] Melhuish TA, Wotton D (diciembre de 2000). «The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF». J. Biol. Chem. 275 (50): 39762-6. PMID 10995736. doi:10.1074/jbc.C000416200.

[pmid9650586-10] Sundqvist A, Sollerbrant K, Svensson C (junio de 1998). «The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex». FEBS Lett. 429 (2): 183-8. PMID 9650586.

[pmid10766745-11] Koipally J, Georgopoulos K (junio de 2000). «Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity». J. Biol. Chem. 275 (26): 19594-602. PMID 10766745. doi:10.1074/jbc.M000254200.

[pmid12444977-12] Perdomo J, Crossley M (diciembre de 2002). «The Ikaros family protein Eos associates with C-terminal-binding protein corepressors». Eur. J. Biochem. 269 (23): 5885-92. PMID 12444977.

[pmid12867035-13] Mirnezami AH, Campbell SJ, Darley M, Primrose JN, Johnson PW, Blaydes JP (julio de 2003). «Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription». Curr. Biol. 13 (14): 1234-9. PMID 12867035.

[pmid12829790-14] Xia ZB, Anderson M, Diaz MO, Zeleznik-Le NJ (julio de 2003). «MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein». Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8342-7. PMC 166231. PMID 12829790. doi:10.1073/pnas.1436338100.

[pmid15060175-15] Castet A, Boulahtouf A, Versini G, Bonnet S, Augereau P, Vignon F, Khochbin S, Jalaguier S, Cavaillès V (2004). «Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition». Nucleic Acids Res. 32 (6): 1957-66. PMC 390375. PMID 15060175. doi:10.1093/nar/gkh524.

[pmid18374649-16] Perissi V, Scafoglio C, Zhang J, Ohgi KA, Rose DW, Glass CK, Rosenfeld MG (marzo de 2008). «TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints». Mol. Cell 29 (6): 755-66. PMC 2364611. PMID 18374649. doi:10.1016/j.molcel.2008.01.020.

[pmid15542832-17] Alpatov R, Munguba GC, Caton P, Joo JH, Shi Y, Shi Y, Hunt ME, Sugrue SP (diciembre de 2004). «Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene». Mol. Cell. Biol. 24 (23): 10223-35. PMC 529029. PMID 15542832. doi:10.1128/MCB.24.23.10223-10235.2004.

[pmid10196224-18] Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH (abril de 1999). «Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage». J. Biol. Chem. 274 (16): 11334-8. PMID 10196224.

[pmid9535825-19] Schaeper U, Subramanian T, Lim L, Boyd JM, Chinnadurai G (abril de 1998). «Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif». J. Biol. Chem. 273 (15): 8549-52. PMID 9535825.

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