La proteína de unión a CREB, también conocido como CREBBP o CBP es una proteína codificada en humanos por el gen CREBBP.[1][2]

Proteína de unión a CREB

Estructura tridimensional de la proteína CREBBP.
Estructuras disponibles
PDB

Buscar ortólogos: PDBe, RCSB PDBe, RCSB

 Lista de códigos PDB
1JSP , 1LIQ , 1RDT , 1WO3 , 1WO4 , 1WO5 , 1WO6 , 1WO7 , 2D82 , 2KJE , 2KWF , 2L84 , 2L85 , 2LXS , 2LXT , 2RNY , 3DWY , 3P1C , 3P1D , 3P1E , 3P1F , 3SVH , 4A9K
 Estructuras enzimáticas
Identificadores
Símbolos CREBBP (HGNC: 2348) CBP; RSTS; RTS
Identificadores
externos
Número EC 2.3.1.48
Locus Cr. 16 p13.3
Patrón de expresión de ARNm
ancho=250px
ancho=250px
Más información
Ortólogos
Especies
Humano Ratón
Entrez
1387 12914
Ensembl
Véase HS Véase MM
UniProt
Q92793 F8VPR5
RefSeq
(ARNm)
NM_001079846 NM_001025432
RefSeq
(proteína) NCBI
NP_001073315 NP_001020603
Ubicación (UCSC)
Cr. 16:
3.78 – 3.93 Mb
Cr. 16:
4.08 – 4.21 Mb
PubMed (Búsqueda)
[1]


[2]

Función

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Este gen esta ubicuamente y está implicado en la co-activación transcripcional de diversos factores de transcripción. El primero fue aislado como una proteína nuclear que se une a proteínas de unión a elementos de respuesta a AMPc (CREB). Este gen es conocido por jugar un papel crítico en el desarrollo embrionario, el control de la proliferación celular y la homeostasis por medio de la reorganización de la cromatina para el reconocimiento de los factores de transcripción. Esta proteína posee una actividad histona acetiltransferasa intrínseca y actúa a su vez como andamio para estabilizar interacciones de proteínas adicionales con el complejo transcripcional. Esta proteína acetila tanto a histonas como a proteínas no histonas. Las CREBBP comparten regiones de una elevada similitud de secuencia con el bromodominio, las regiones ricas en cisteína-histidina y el dominio histona acetiltransferasa de la proteína EP300.[3]

Importancia clínica

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Mutaciones en este gen son las causantes del síndrome de Rubinstein-Taybi (RTS).[4]​ Se han asociado diversas traslocaciones cromosómicas de este gen con la leucemia mieloide aguda.[3][5]

Interacciones

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La proteína CREBBP ha demostrado ser capaz de interaccionar con:

Véase también

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Referencias

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  1. Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH (octubre de 1993). «Phosphorylated CREB binds specifically to the nuclear protein CBP». Nature 365 (6449): 855-9. PMID 8413673. doi:10.1038/365855a0. 
  2. Wydner KL, Bhattacharya S, Eckner R, Lawrence JB, Livingston DM (noviembre de 1995). «Localization of human CREB-binding protein gene (CREBBP) to 16p13.2-p13.3 by fluorescence in situ hybridization». Genomics 30 (2): 395-6. PMID 8586450. 
  3. a b «Entrez Gene: CREBBP (CREB-binding protein)». 
  4. Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ (julio de 1995). «Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP». Nature 376 (6538): 348-51. PMID 7630403. doi:10.1038/376348a0. 
  5. Vizmanos JL, Larráyoz MJ, Lahortiga I, Floristán F, Alvarez C, Odero MD, Novo FJ, Calasanz MJ (abril de 2003). «t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia». Genes Chromosomes Cancer 36 (4): 402-5. PMID 12619164. doi:10.1002/gcc.10174. 
  6. a b c Sano, Y; Tokitou F; Dai P; Maekawa T; Yamamoto T; Ishii S (Oct. de 1998). «CBP alleviates the intramolecular inhibition of ATF-2 function». J. Biol. Chem. (UNITED STATES) 273 (44): 29098-105. ISSN 0021-9258. PMID 9786917. doi:10.1074/jbc.273.44.29098. 
  7. a b Kim, J; Jia L, Stallcup M R, Coetzee G A (Feb. de 2005). «The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus». J. Mol. Endocrinol. (England) 34 (1): 107-18. ISSN 0952-5041. PMID 15691881. doi:10.1677/jme.1.01701. 
  8. Frønsdal, K; Engedal N; Slagsvold T; Saatcioglu F (Nov. de 1998). «CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1». J. Biol. Chem. (UNITED STATES) 273 (48): 31853-9. ISSN 0021-9258. PMID 9822653. doi:10.1074/jbc.273.48.31853. 
  9. Ishitani, Ken; Yoshida Tasuku, Kitagawa Hirochika, Ohta Hiroaki, Nozawa Shiro, Kato Shigeaki (Jul. de 2003). «p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor». Biochem. Biophys. Res. Commun. (United States) 306 (3): 660-5. ISSN 0006-291X. PMID 12810069. doi:10.1016/S0006-291X(03)01021-0. 
  10. a b Aarnisalo, P; Palvimo J J, Jänne O A (Mar. de 1998). «CREB-binding protein in androgen receptor-mediated signaling». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (5): 2122-7. ISSN 0027-8424. PMC 19270. PMID 9482849. doi:10.1073/pnas.95.5.2122. 
  11. Pitkänen, J; Doucas V, Sternsdorf T, Nakajima T, Aratani S, Jensen K, Will H, Vähämurto P, Ollila J, Vihinen M, Scott H S, Antonarakis S E, Kudoh J, Shimizu N, Krohn K, Peterson P (Jun. de 2000). «The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein». J. Biol. Chem. (UNITED STATES) 275 (22): 16802-9. ISSN 0021-9258. PMID 10748110. doi:10.1074/jbc.M908944199. 
  12. Iioka, Takashi; Furukawa Keizo, Yamaguchi Akira, Shindo Hiroyuki, Yamashita Shunichi, Tsukazaki Tomoo (Aug. de 2003). «P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain». J. Bone Miner. Res. (United States) 18 (8): 1419-29. ISSN 0884-0431. PMID 12929931. doi:10.1359/jbmr.2003.18.8.1419. 
  13. a b c Fan, Saijun; Ma Yong Xian, Wang Chenguang, Yuan Ren-Qi, Meng Qinghui, Wang Ji-An, Erdos Michael, Goldberg Itzhak D, Webb Paul, Kushner Peter J, Pestell Richard G, Rosen Eliot M (Jan. de 2002). «p300 Modulates the BRCA1 inhibition of estrogen receptor activity». Cancer Res. (United States) 62 (1): 141-51. ISSN 0008-5472. PMID 11782371. 
  14. Pao, G M; Janknecht R, Ruffner H, Hunter T, Verma I M (Feb. de 2000). «CBP/p300 interact with and function as transcriptional coactivators of BRCA1». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (3): 1020-5. ISSN 0027-8424. PMC 15508. PMID 10655477. doi:10.1073/pnas.97.3.1020. 
  15. Chai, Y L; Cui J, Shao N, Shyam E, Reddy P, Rao V N (Jan. de 1999). «The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter». Oncogene (ENGLAND) 18 (1): 263-8. ISSN 0950-9232. PMID 9926942. doi:10.1038/sj.onc.1202323. 
  16. Benezra, Miriam; Chevallier Nathalie, Morrison Debra J, MacLachlan Timothy K, El-Deiry Wafik S, Licht Jonathan D (Jul. de 2003). «BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit». J. Biol. Chem. (United States) 278 (29): 26333-41. ISSN 0021-9258. PMID 12700228. doi:10.1074/jbc.M303076200. 
  17. a b Neish, A S; Anderson S F, Schlegel B P, Wei W, Parvin J D (Feb. de 1998). «Factors associated with the mammalian RNA polymerase II holoenzyme». Nucleic Acids Res. (ENGLAND) 26 (3): 847-53. ISSN 0305-1048. PMC 147327. PMID 9443979. doi:10.1093/nar/26.3.847. 
  18. Kawabuchi, M; Satomi Y; Takao T; Shimonishi Y; Nada S; Nagai K; Tarakhovsky A; Okada M (Apr. de 2000). «Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases». Nature (ENGLAND) 404 (6781): 999-1003. ISSN 0028-0836. PMID 10801129. doi:10.1038/35010121. 
  19. a b Yamaguchi, Y; Wada T; Suzuki F; Takagi T; Hasegawa J; Handa H (Aug. de 1998). «Casein kinase II interacts with the bZIP domains of several transcription factors». Nucleic Acids Res. (ENGLAND) 26 (16): 3854-61. ISSN 0305-1048. PMC 147779. PMID 9685505. doi:10.1093/nar/26.16.3854. 
  20. Kovacs KA, Steinmann M; Magistretti PJ; Halfon O; Cardinaux JR (Sept. de 2003). «CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation». J Biol. Chem. (UNITED STATES) 278 (38): 36959-65. ISSN 0021-9258. PMID 12857754. doi:10.1074/jbc.M303147200. 
  21. Lorentz, O; Suh E R, Taylor J K, Boudreau F, Traber P G (Mar. de 1999). «CREB-binding [corrected] protein interacts with the homeodomain protein Cdx2 and enhances transcriptional activity». J. Biol. Chem. (UNITED STATES) 274 (11): 7196-9. ISSN 0021-9258. PMID 10066780. doi:10.1074/jbc.274.11.7196. 
  22. Shi, Yuling; Venkataraman Sujatha L, Dodson Gerald E, Mabb Angela M, LeBlanc Scott, Tibbetts Randal S (Apr. de 2004). «Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress». Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (16): 5898-903. ISSN 0027-8424. PMC 395895. PMID 15073328. doi:10.1073/pnas.0307718101. 
  23. Shimomura, A; Ogawa Y; Kitani T; Fujisawa H; Hagiwara M (Jul. de 1996). «Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein». J. Biol. Chem. (UNITED STATES) 271 (30): 17957-60. ISSN 0021-9258. PMID 8663317. doi:10.1074/jbc.271.30.17957. 
  24. Radhakrishnan, I; Pérez-Alvarado G C, Parker D, Dyson H J, Montminy M R, Wright P E (Dec. de 1997). «Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions». Cell (UNITED STATES) 91 (6): 741-52. ISSN 0092-8674. PMID 9413984. doi:10.1016/S0092-8674(00)80463-8. 
  25. a b Zor, Tsaffrir; Mayr Bernhard M, Dyson H Jane, Montminy Marc R, Wright Peter E (Nov. de 2002). «Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators». J. Biol. Chem. (United States) 277 (44): 42241-8. ISSN 0021-9258. PMID 12196545. doi:10.1074/jbc.M207361200. 
  26. a b Giebler, H A; Lemasson I, Nyborg J K (Jul. de 2000). «p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation». Mol. Cell. Biol. (UNITED STATES) 20 (13): 4849-58. ISSN 0270-7306. PMC 85936. PMID 10848610. doi:10.1128/MCB.20.13.4849-4858.2000. 
  27. a b Zhang, Q; Vo N, Goodman R H (Jul. de 2000). «Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB». Mol. Cell. Biol. (UNITED STATES) 20 (14): 4970-8. ISSN 0270-7306. PMC 85947. PMID 10866654. doi:10.1128/MCB.20.14.4970-4978.2000. 
  28. a b Ernst, P; Wang J, Huang M, Goodman R H, Korsmeyer S J (Apr. de 2001). «MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein». Mol. Cell. Biol. (United States) 21 (7): 2249-58. ISSN 0270-7306. PMC 86859. PMID 11259575. doi:10.1128/MCB.21.7.2249-2258.2001. 
  29. Ledo, Fran; Kremer Leonor, Mellström Britt, Naranjo Jose R (Sep. de 2002). «Ca2+-dependent block of CREB-CBP transcription by repressor DREAM». EMBO J. (England) 21 (17): 4583-92. ISSN 0261-4189. PMC 126180. PMID 12198160. doi:10.1093/emboj/cdf440. 
  30. Li, S; Aufiero B, Schiltz R L, Walsh M J (Jun. de 2000). «Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (13): 7166-71. ISSN 0027-8424. PMC 16517. PMID 10852958. doi:10.1073/pnas.130028697. 
  31. a b c d Cho, H; Orphanides G, Sun X, Yang X J, Ogryzko V, Lees E, Nakatani Y, Reinberg D (Sep. de 1998). «A human RNA polymerase II complex containing factors that modify chromatin structure». Mol. Cell. Biol. (UNITED STATES) 18 (9): 5355-63. ISSN 0270-7306. PMC 109120. PMID 9710619. 
  32. Zhao, Fang; McCarrick-Walmsley Ruth, Akerblad Peter, Sigvardsson Mikael, Kadesch Tom (Jun. de 2003). «Inhibition of p300/CBP by early B-cell factor». Mol. Cell. Biol. (United States) 23 (11): 3837-46. ISSN 0270-7306. PMC 155219. PMID 12748286. doi:10.1128/MCB.23.11.3837-3846.2003. 
  33. a b Sheppard, H M; Harries J C, Hussain S, Bevan C, Heery D M (Jan. de 2001). «Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1». Mol. Cell. Biol. (UNITED STATES) 21 (1): 39-50. ISSN 0270-7306. PMC 86566. PMID 11113179. doi:10.1128/MCB.21.1.39-50.2001. 
  34. Chakraborty, S; Senyuk V; Sitailo S; Chi Y; Nucifora G (Nov. de 2001). «Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles». J. Biol. Chem. (United States) 276 (48): 44936-43. ISSN 0021-9258. PMID 11568182. doi:10.1074/jbc.M106733200. 
  35. Nasrin, N; Ogg S, Cahill C M, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges M C (Sep. de 2000). «DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (19): 10412-7. ISSN 0027-8424. PMC 27038. PMID 10973497. doi:10.1073/pnas.190326997. 
  36. Dai, P; Akimaru H; Tanaka Y; Maekawa T; Nakafuku M; Ishii S (Mar. de 1999). «Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3». J. Biol. Chem. (UNITED STATES) 274 (12): 8143-52. ISSN 0021-9258. PMID 10075717. doi:10.1074/jbc.274.12.8143. 
  37. Almlöf, T; Wallberg A E, Gustafsson J A, Wright A P (Jun. de 1998). «Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors». Biochemistry (UNITED STATES) 37 (26): 9586-94. ISSN 0006-2960. PMID 9649342. doi:10.1021/bi973029x. 
  38. Yoshida, E; Aratani S; Itou H; Miyagishi M; Takiguchi M; Osumu T; Murakami K; Fukamizu A (Dec. de 1997). «Functional association between CBP and HNF4 in trans-activation». Biochem. Biophys. Res. Commun. (UNITED STATES) 241 (3): 664-9. ISSN 0006-291X. PMID 9434765. doi:10.1006/bbrc.1997.7871. 
  39. Dell, H; Hadzopoulou-Cladaras M (Mar. de 1999). «CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression». J. Biol. Chem. (UNITED STATES) 274 (13): 9013-21. ISSN 0021-9258. PMID 10085149. doi:10.1074/jbc.274.13.9013. 
  40. Ema, M; Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y (Apr. de 1999). «Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300». EMBO J. (ENGLAND) 18 (7): 1905-14. ISSN 0261-4189. PMC 1171276. PMID 10202154. doi:10.1093/emboj/18.7.1905. 
  41. Bhattacharya, S; Michels C L, Leung M K, Arany Z P, Kung A L, Livingston D M (Jan. de 1999). «Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1». Genes Dev. (UNITED STATES) 13 (1): 64-75. ISSN 0890-9369. PMC 316375. PMID 9887100. doi:10.1101/gad.13.1.64. 
  42. Park, Young-Kwon; Ahn Dae-Ro, Oh Myoungsuk, Lee Taekyoung, Yang Eun Gyeong, Son Miwon, Park Hyunsung (Jul. de 2008). «Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation». Mol. Pharmacol. (United States) 74 (1): 236-45. PMID 18426857. doi:10.1124/mol.108.045278. 
  43. Hofmann, Thomas G; Möller Andreas, Sirma Hüaeyin, Zentgraf Hanswalter, Taya Yoichi, Dröge Wulf, Will Hans, Schmitz M Lienhard (Jan. de 2002). «Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2». Nat. Cell Biol. (England) 4 (1): 1-10. ISSN 1465-7392. PMID 11740489. doi:10.1038/ncb715. 
  44. Soutoglou, E; Papafotiou G; Katrakili N; Talianidis I (Apr. de 2000). «Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins». J. Biol. Chem. (UNITED STATES) 275 (17): 12515-20. ISSN 0021-9258. PMID 10777539. doi:10.1074/jbc.275.17.12515. 
  45. Chariot, A; van Lint C, Chapelier M, Gielen J, Merville M P, Bours V (Jul. de 1999). «CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein». Oncogene (ENGLAND) 18 (27): 4007-14. ISSN 0950-9232. PMID 10435624. doi:10.1038/sj.onc.1202776. 
  46. Vieyra, Diego; Loewith Robbie, Scott Michelle, Bonnefin Paul, Boisvert Francois-Michel, Cheema Parneet, Pastyryeva Svitlana, Meijer Maria, Johnston Randal N, Bazett-Jones David P, McMahon Steven, Cole Michael D, Young Dallan, Riabowol Karl (Aug. de 2002). «Human ING1 proteins differentially regulate histone acetylation». J. Biol. Chem. (United States) 277 (33): 29832-9. ISSN 0021-9258. PMID 12015309. doi:10.1074/jbc.M200197200. 
  47. Hong, Wei; Resnick Ross J, Rakowski Carrie, Shalloway David, Taylor Steven J, Blobel Gerd A (Nov. de 2002). «Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68». Mol. Cancer Res. (United States) 1 (1): 48-55. ISSN 1541-7786. PMID 12496368. 
  48. Song, Chao-Zhong; Keller Kimberly, Murata Ken, Asano Haruhiko, Stamatoyannopoulos George (Mar. de 2002). «Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2». J. Biol. Chem. (United States) 277 (9): 7029-36. ISSN 0021-9258. PMC 2808425. PMID 11748222. doi:10.1074/jbc.M108826200. 
  49. Geiman, D E; Ton-That H, Johnson J M, Yang V W (Mar. de 2000). «Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction». Nucleic Acids Res. (ENGLAND) 28 (5): 1106-13. PMC 102607. PMID 10666450. doi:10.1093/nar/28.5.1106. 
  50. Barlev, N A; Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman J L, Berger S L (Mar. de 1998). «Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex». Mol. Cell. Biol. (UNITED STATES) 18 (3): 1349-58. ISSN 0270-7306. PMC 108848. PMID 9488450. 
  51. Chen, Qin; Dowhan Dennis H, Liang Dongcai, Moore David D, Overbeek Paul A (Jul. de 2002). «CREB-binding protein/p300 co-activation of crystallin gene expression». J. Biol. Chem. (United States) 277 (27): 24081-9. ISSN 0021-9258. PMID 11943779. doi:10.1074/jbc.M201821200. 
  52. Goto, Natalie K; Zor Tsaffrir, Martinez-Yamout Maria, Dyson H Jane, Wright Peter E (Nov. de 2002). «Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain». J. Biol. Chem. (United States) 277 (45): 43168-74. ISSN 0021-9258. PMID 12205094. doi:10.1074/jbc.M207660200. 
  53. Pearson, K L; Hunter T; Janknecht R (Dec. de 1999). «Activation of Smad1-mediated transcription by p300/CBP». Biochim. Biophys. Acta (NETHERLANDS) 1489 (2-3): 354-64. ISSN 0006-3002. PMID 10673036. 
  54. a b Sun, Y; Nadal-Vicens M, Misono S, Lin M Z, Zubiaga A, Hua X, Fan G, Greenberg M E (Feb. de 2001). «Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms». Cell (United States) 104 (3): 365-76. ISSN 0092-8674. PMID 11239394. doi:10.1016/S0092-8674(01)00224-0. 
  55. Shetty, S; Takahashi T; Matsui H; Ayengar R; Raghow R (mayo. de 1999). «Transcriptional autorepression of Msx1 gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding protein, Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300)». Biochem. J. (ENGLAND). 339 ( Pt 3): 751-8. ISSN 0264-6021. PMC 1220213. PMID 10215616. doi:10.1042/0264-6021:3390751. 
  56. a b Bessa, M; Saville M K, Watson R J (Jun. de 2001). «Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator». Oncogene (England) 20 (26): 3376-86. ISSN 0950-9232. PMID 11423988. doi:10.1038/sj.onc.1204439. 
  57. Polesskaya, A; Naguibneva I, Duquet A, Bengal E, Robin P, Harel-Bellan A (Aug. de 2001). «Interaction between acetylated MyoD and the bromodomain of CBP and/or p300». Mol. Cell. Biol. (United States) 21 (16): 5312-20. ISSN 0270-7306. PMC 87255. PMID 11463815. doi:10.1128/MCB.21.16.5312-5320.2001. 
  58. Sartorelli, V; Huang J; Hamamori Y; Kedes L (Feb. de 1997). «Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C». Mol. Cell. Biol. (UNITED STATES) 17 (2): 1010-26. ISSN 0270-7306. PMC 231826. PMID 9001254. 
  59. Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. de 1999). «A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo». J. Biol. Chem. (UNITED STATES) 274 (48): 34283-93. ISSN 0021-9258. PMID 10567404. doi:10.1074/jbc.274.48.34283. 
  60. Lee, S K; Jung S Y, Kim Y S, Na S Y, Lee Y C, Lee J W (Feb. de 2001). «Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2». Mol. Endocrinol. (United States) 15 (2): 241-54. ISSN 0888-8809. PMID 11158331. doi:10.1210/me.15.2.241. 
  61. Yang, T; Davis R J, Chow C W (Oct. de 2001). «Requirement of two NFATc4 transactivation domains for CBP potentiation». J. Biol. Chem. (United States) 276 (43): 39569-76. ISSN 0021-9258. PMID 11514544. doi:10.1074/jbc.M102961200. 
  62. Hung, H L; Kim A Y, Hong W, Rakowski C, Blobel G A (Apr. de 2001). «Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation». J. Biol. Chem. (United States) 276 (14): 10715-21. ISSN 0021-9258. PMID 11154691. doi:10.1074/jbc.M007846200. 
  63. Katoh, Y; Itoh K; Yoshida E; Miyagishi M; Fukamizu A; Yamamoto M (Oct. de 2001). «Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription». Genes Cells (England) 6 (10): 857-68. ISSN 1356-9597. PMID 11683914. doi:10.1046/j.1365-2443.2001.00469.x. 
  64. a b Wu, Ray-Chang; Qin Jun, Hashimoto Yoshihiro, Wong Jiemin, Xu Jianming, Tsai Sophia Y, Tsai Ming-Jer, O'Malley Bert W (mayo. de 2002). «Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase». Mol. Cell. Biol. (United States) 22 (10): 3549-61. ISSN 0270-7306. PMC 133790. PMID 11971985. doi:10.1128/MCB.22.10.3549-3561.2002. 
  65. Naltner, A; Wert S, Whitsett J A, Yan C (Dec. de 2000). «Temporal/spatial expression of nuclear receptor coactivators in the mouse lung». Am. J. Physiol. Lung Cell Mol. Physiol. (UNITED STATES) 279 (6): L1066-74. ISSN 1040-0605. PMID 11076796. 
  66. Kasper, L H; Brindle P K, Schnabel C A, Pritchard C E, Cleary M L, van Deursen J M (Jan. de 1999). «CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity». Mol. Cell. Biol. (UNITED STATES) 19 (1): 764-76. ISSN 0270-7306. PMC 83933. PMID 9858599. 
  67. Ito, Akihiro; Kawaguchi Yoshiharu, Lai Chun-Hsiang, Kovacs Jeffrey J, Higashimoto Yuichiro, Appella Ettore, Yao Tso-Pang (Nov. de 2002). «MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation». EMBO J. (England) 21 (22): 6236-45. ISSN 0261-4189. PMC 137207. PMID 12426395. doi:10.1093/emboj/cdf616. 
  68. Livengood, Jill A; Scoggin Kirsten E S, Van Orden Karen, McBryant Steven J, Edayathumangalam Rajeswari S, Laybourn Paul J, Nyborg Jennifer K (Mar. de 2002). «p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300». J. Biol. Chem. (United States) 277 (11): 9054-61. ISSN 0021-9258. PMID 11782467. doi:10.1074/jbc.M108870200. 
  69. a b c Tini, Marc; Benecke Arndt, Um Soo-Joong, Torchia Joseph, Evans Ronald M, Chambon Pierre (Feb. de 2002). «Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription». Mol. Cell (United States) 9 (2): 265-77. ISSN 1097-2765. PMID 11864601. doi:10.1016/S1097-2765(02)00453-7. 
  70. Puigserver, P; Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman B M (Nov. de 1999). «Activation of PPARgamma coactivator-1 through transcription factor docking». Science (UNITED STATES) 286 (5443): 1368-71. ISSN 0036-8075. PMID 10558993. doi:10.1126/science.286.5443.1368. 
  71. a b Matsuzaki, Kazuhito; Minami Takeshi, Tojo Masahide, Honda Yoshiomi, Saitoh Noriko, Nagahiro Shinji, Saya Hideyuki, Nakao Mitsuyoshi (Mar. de 2003). «PML-nuclear bodies are involved in cellular serum response». Genes Cells (England) 8 (3): 275-86. ISSN 1356-9597. PMID 12622724. doi:10.1046/j.1365-2443.2003.00632.x. 
  72. Doucas, V; Tini M, Egan D A, Evans R M (Mar. de 1999). «Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (6): 2627-32. ISSN 0027-8424. PMC 15819. PMID 10077561. doi:10.1073/pnas.96.6.2627. 
  73. Zhong, S; Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman L P, Pandolfi P P (Nov. de 1999). «A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins». Nat. Genet. (UNITED STATES) 23 (3): 287-95. ISSN 1061-4036. PMID 10610177. doi:10.1038/15463. 
  74. Karetsou, Zoe; Kretsovali Adroniki, Murphy Carol, Tsolas Orestes, Papamarcaki Thomais (Apr. de 2002). «Prothymosin alpha interacts with the CREB-binding protein and potentiates transcription». EMBO Rep. (England) 3 (4): 361-6. ISSN 1469-221X. PMC 1084059. PMID 11897665. doi:10.1093/embo-reports/kvf071. 
  75. Jang, Hyun Duk; Yoon Kwiyeom, Shin Young Joo, Kim Jaesang, Lee Soo Young (Jun. de 2004). «PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit». J. Biol. Chem. (United States) 279 (23): 24873-80. ISSN 0021-9258. PMID 15140884. doi:10.1074/jbc.M313018200. 
  76. Zhong, Haihong; May Michael J, Jimi Eijiro, Ghosh Sankar (Mar. de 2002). «The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1». Mol. Cell (United States) 9 (3): 625-36. ISSN 1097-2765. PMID 11931769. doi:10.1016/S1097-2765(02)00477-X. 
  77. Parry, G C; Mackman N (Dec. de 1997). «Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription». J. Immunol. (UNITED STATES) 159 (11): 5450-6. ISSN 0022-1767. PMID 9548485. 
  78. Gerritsen, M E; Williams A J, Neish A S, Moore S, Shi Y, Collins T (Apr. de 1997). «CREB-binding protein/p300 are transcriptional coactivators of p65». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (7): 2927-32. ISSN 0027-8424. PMC 20299. PMID 9096323. doi:10.1073/pnas.94.7.2927. 
  79. Merienne, K; Pannetier S, Harel-Bellan A, Sassone-Corsi P (Oct. de 2001). «Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities». Mol. Cell. Biol. (United States) 21 (20): 7089-96. ISSN 0270-7306. PMC 99884. PMID 11564891. doi:10.1128/MCB.21.20.7089-7096.2001. 
  80. Hirose, Takuji; Fujii Ryouji, Nakamura Hiroshi, Aratani Satoko, Fujita Hidetoshi, Nakazawa Minako, Nakamura Kohzo, Nishioka Kusuki, Nakajima Toshihiro (Jun. de 2003). «Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP». Int. J. Mol. Med. (Greece) 11 (6): 705-12. ISSN 1107-3756. PMID 12736710. 
  81. DiRenzo, J; Shang Y; Phelan M; Sif S; Myers M; Kingston R; Brown M (Oct. de 2000). «BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation». Mol. Cell. Biol. (UNITED STATES) 20 (20): 7541-9. ISSN 0270-7306. PMC 86306. PMID 11003650. doi:10.1128/MCB.20.20.7541-7549.2000. 
  82. a b Oliner, J D; Andresen J M, Hansen S K, Zhou S, Tjian R (Nov. de 1996). «SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein». Genes Dev. (UNITED STATES) 10 (22): 2903-11. ISSN 0890-9369. PMID 8918891. doi:10.1101/gad.10.22.2903. 
  83. Aizawa, Hiroyuki; Hu Shu-Ching, Bobb Kathryn, Balakrishnan Karthik, Ince Gulayse, Gurevich Inga, Cowan Mitra, Ghosh Anirvan (Jan. de 2004). «Dendrite development regulated by CREST, a calcium-regulated transcriptional activator». Science (United States) 303 (5655): 197-202. PMID 14716005. doi:10.1126/science.1089845. 
  84. Zhang, J J; Vinkemeier U, Gu W, Chakravarti D, Horvath C M, Darnell J E (Dec. de 1996). «Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (26): 15092-6. ISSN 0027-8424. PMC 26361. PMID 8986769. doi:10.1073/pnas.93.26.15092. 
  85. Bhattacharya, S; Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston D M (Sep. de 1996). «Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha». Nature (ENGLAND) 383 (6598): 344-7. ISSN 0028-0836. PMID 8848048. doi:10.1038/383344a0. 
  86. Litterst, C M; Pfitzner E (Dec. de 2001). «Transcriptional activation by STAT6 requires the direct interaction with NCoA-1». J. Biol. Chem. (United States) 276 (49): 45713-21. ISSN 0021-9258. PMID 11574547. doi:10.1074/jbc.M108132200. 
  87. McDonald, C; Reich N C (Jul. de 1999). «Cooperation of the transcriptional coactivators CBP and p300 with Stat6». J. Interferon Cytokine Res. (UNITED STATES) 19 (7): 711-22. ISSN 1079-9907. PMID 10454341. doi:10.1089/107999099313550. 
  88. Bradney, Curtis; Hjelmeland Mark, Komatsu Yasuhiko, Yoshida Minoru, Yao Tso-Pang, Zhuang Yuan (Jan. de 2003). «Regulation of E2A activities by histone acetyltransferases in B lymphocyte development». J. Biol. Chem. (United States) 278 (4): 2370-6. ISSN 0021-9258. PMID 12435739. doi:10.1074/jbc.M211464200. 
  89. Misra, Parimal; Qi Chao, Yu Songtao, Shah Sejal H, Cao Wen-Qing, Rao M Sambasiva, Thimmapaya Bayar, Zhu Yijun, Reddy Janardan K (mayo. de 2002). «Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation». J. Biol. Chem. (United States) 277 (22): 20011-9. ISSN 0021-9258. PMID 11912212. doi:10.1074/jbc.M201739200. 
  90. Gizard, F; Lavallée B, DeWitte F, Hum D W (Sep. de 2001). «A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression». J. Biol. Chem. (United States) 276 (36): 33881-92. ISSN 0021-9258. PMID 11349124. doi:10.1074/jbc.M100113200. 
  91. Silverman, E S; Du J, Williams A J, Wadgaonkar R, Drazen J M, Collins T (Nov. de 1998). «cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1)». Biochem. J. (ENGLAND). 336 ( Pt 1): 183-9. ISSN 0264-6021. PMC 1219856. PMID 9806899. 

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